In 2001, James Paul O’Neill became a graduate of The Royal College of Surgeons in Ireland (RCSI) winning both the RCSI Council Medal and the Dr Jim Mahon Medal for Medicine. In 2004, he became a Fellow of RCSI. He completed his Doctorate of Medicine and won the Sir Angell James Prize for ENT research in London on Thyroid Cancer.

In 2006 he studied in the Smurfit Business School at University College Dublin completing an Executive Masters of Business Administration. In 2010 he was awarded his Intercollegiate in Otolaryngology and also completed a Masters in Medical Education in Queens University Belfast.

In July 2010 he began a surgical oncology fellowship in Head and Neck Surgical Oncology at Memorial Sloan Kettering Cancer Center in New York. He has published research papers, book chapters and two textbooks with Elsevier publishers on Head & Neck disease and Otolaryngology. In 2014 he was appointed Professor of Otolaryngology, Head and Neck Surgery at RCSI.

He operates on all aspects of Otolaryngology disease and specialises in cancers of the Head, Neck and Skullbase, Thyroid cancer, Sinus and Salivary disease.